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Skin Conditioning

PENTAPEPTIDE-66

84

Safety score · 0–100

Good

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A short synthetic pentapeptide based on histidine, isoleucine and valine, used in skincare for skin conditioning and protection. Clean low-irritation safety profile and no significant documented concerns at cosmetic use levels.

Skin benefits

  • Composed of common, well-tolerated amino acids
  • Used for skin conditioning and texture
  • Stable at typical formulation pH
  • Low irritation potential at cosmetic use levels

Known concerns

  • Limited independent efficacy data
  • Activity is supplier and concentration dependent

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.