Skin Conditioning
PENTAPEPTIDE-81
Safety score · 0–100
Fine
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
A synthetic five-amino-acid peptide used as a skin-conditioning agent. Designer peptide with limited public safety/efficacy literature.
Pentapeptide-81 is a five-residue synthetic peptide developed for cosmetic skin-conditioning use. Pentapeptides in cosmetics are typically dosed at parts-per-million levels in serums and creams and are generally considered low-irritation due to poor penetration and rapid degradation. No independent CIR or SCCS review of this specific INCI is available; efficacy claims rely predominantly on supplier-sponsored studies. Listed in EU CosIng. Conservative tier: yellow with low evidence.
Function
Skin benefits
- Trace-level skin conditioning
- Compatible with sensitive-skin formats
- Low sensitization potential
Known concerns
- Limited independent safety data
- No CIR/SCCS monograph
- Supplier-driven efficacy claims
References
EU CosIng database
European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.
Related skin conditionings
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.