Solvent
PERFLUOROMETHYLCYCLOHEXANE
Safety score · 0–100
Caution
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A fluorocarbon solvent in the PFAS family. Largely inert biologically, but extremely persistent — modern cosmetic regulation is phasing this class out.
Perfluoromethylcyclohexane (CAS 355-02-2) is a fully fluorinated cyclohexane — methylcyclohexane in which every hydrogen is replaced by fluorine. Chemically it is almost perfectly inert (low acute toxicity, no biological activity), which led to niche uses as a high-density solvent and historic use in some specialty cosmetic delivery systems. The problem is environmental: it is a PFAS — per- and polyfluoroalkyl substance — and carbon-fluorine bonds are essentially non-degradable under environmental conditions. PFAS ingredients are globally restricted under the EU's PFAS restriction proposal (REACH), EPA rulings in the US, and state-level cosmetic PFAS bans (California, Maryland, New York). The compound also has a very high global warming potential. Use in cosmetics is rapidly becoming non-compliant regardless of its low biological toxicity.
Function
Skin benefits
- Highly inert fluorocarbon solvent
- Unique oxygen-carrying property — used historically in some niche formulations
- Low acute toxicity at exposure
Known concerns
- PFAS (per- and polyfluoroalkyl substance) — extremely environmentally persistent
- EU and US regulators are progressively restricting PFAS in cosmetics
- Bioaccumulation concerns
- Strong greenhouse gas (very high GWP)
- Not appropriate for cosmetic use under modern regulatory trajectory
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related solvents
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.