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Phenobarbital

CAS 50-06-6
5

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Phenobarbital is a cosmetic ingredient. Exercise caution due to limited available safety data.

Phenobarbital is a long-acting barbiturate with profound CNS depressant effects. It is classified as a CMR (Carcinogenic, Mutagenic, Reprotoxic) substance under EU regulation and is listed on Annex II of the Cosmetics Regulation, making it absolutely prohibited in cosmetic products. Multiple hazard statements including H350 (carcinogen), H360 (reprotoxic), and H340 (mutagen) confirm its unsuitability.

Known concerns

  • CMR substance - banned in EU cosmetics (Annex II)
  • Known carcinogen (H350)
  • Reprotoxic (H360)
  • Mutagenic (H340)
  • Acute oral toxicity (H301)
  • Skin sensitiser (H317)

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.