Other
Phenol, 2,2'- methylenebis[4- amino-], dihydrochloride
Safety score · 0–100
Caution
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
An aromatic diamine structurally related to sensitizing hair dye intermediates, requiring careful safety evaluation before cosmetic use.
This methylene-bridged aromatic diamine presents structural concern due to its similarity to known sensitizers in the p-phenylenediamine class. The dihydrochloride salt increases water solubility and potential for dermal penetration. Safety assessment is complicated by the lack of comprehensive toxicological data in available literature; it is not formally restricted but carries implicit concern.
Known concerns
- Structural similarity to sensitizing hair dye intermediates
- Enhanced dermal penetration as salt form
- Limited comprehensive toxicological data
- Potential for cross-reactivity in PPD-sensitized individuals
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related others
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.