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Phenol, 2-Amino- 5-Ethyl-, Hydrochloride

35

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Phenol, 2-amino- 5-ethyl-, Hydrochloride is a cosmetic ingredient used in product formulations. Exercise caution due to limited available safety data.

2-Amino-5-ethylphenol hydrochloride is an aromatic amine salt flagged for potential formation of carcinogenic aromatic amine derivatives under skin metabolism. EU Regulation 1223/2009 Annex III restricts a number of aromatic amines in cosmetic products, requiring that they do not exceed specific concentration limits and that they be tested for compliance with the Solubility of Primary Aromatic Amines standard. The hydrochloride salt form is more water-soluble than the free base, increasing potential for dermal penetration. SCCS opinions on aromatic amines indicate genotoxicity concern for structures metabolizable to nitroso intermediates.

Known concerns

  • Aromatic amine - potential nitrosation and carcinogenic conversion in skin
  • EU Annex III restricted - requires specific concentration limits
  • May cause skin discoloration (oxidation to quinone-imine)
  • Limited safety data for cosmetic topical use

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.