PHENYLETHYLIDENE-BIS-INDOLE
Safety score · 0–100
Fine
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
Phenylethylidene-bis-indole is a cosmetic ingredient used in product formulations. Exercise caution due to limited available safety data.
Phenylethylidene-bis-indole (also known as 1,1-bis(2-indolyl)phenylmethane or indole, 1,1'-(phenylmethylene)bis-) is a synthetic fragrance ingredient that provides a powerful, persistent floral scent reminiscent of jasmine. It is used at very low concentrations (typically 0.01-0.1%) as a fragrance component in fine fragrance, skin care, and hair care products. Indole and its derivatives are subject to IFRA (International Fragrance Association) standards, which restrict their use based on sensitisation data. The SCCS has noted concerns about certain indole derivatives in cosmetic products, particularly in leave-on applications.
Known concerns
- Indole derivative - strong fragrance component
- May cause sensitisation at high concentrations
- Used at low concentrations as a fragrance ingredient
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.