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PIPERLONGUMINE

CAS 20069-09-4
45

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A piperine analog from Piper longum fruits with limited cosmetic safety data and potential skin penetration effects.

Piperlongumine (also called piplartine) is an alkaloid amide found in Piper longum (long pepper) fruits. Like piperine, it exhibits various biological activities including potential skin penetration enhancement. However, toxicological data specifically for cosmetic topical use is limited. Some studies suggest cytotoxic effects at certain concentrations, requiring caution. Not listed in EU restriction annexes but not extensively reviewed for cosmetics either.

Known concerns

  • Limited cosmetic safety data
  • Potential cytotoxicity at higher concentrations
  • Skin penetration enhancement may increase co-ingredient absorption

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.