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PIPERONYL ACETATE

CAS 326-61-4
55

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

An aromatic methylene-dioxy benzene acetate with a sweet, balsamic, vanilla-like fragrance; requires caution due to the piperonyl structural class and sensitization concerns.

Piperonyl acetate is the acetate ester of piperonyl alcohol, containing the characteristic methylenedioxyphenyl (MDP) ring system found in safrole and related compounds. Some MDP compounds are listed in EU Annex II for carcinogenicity concerns (e.g., safrole). While piperonyl acetate itself is not specifically restricted in CosIng, the structural alerts associated with the MDP group and documented skin sensitization reports in related compounds warrant a cautious safety score and a lower range classification.

Skin benefits

  • Sweet balsamic fragrance with vanilla undertones

Known concerns

  • Structural alerts for carcinogenicity (MDP group)
  • Documented skin sensitization in related MDP compounds
  • EU regulatory scrutiny of MDP compounds

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.