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PIPERONYL BUTOXIDE

CAS 51-03-6
35

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A methylenedioxyphenyl insecticide synergist commonly used in pesticide formulations (especially head lice treatments) but not authorized as a cosmetic ingredient in the EU.

Piperonyl butoxide (PBO) is a methylenedioxyphenyl synergist that inhibits cytochrome P450 enzymes, thereby potentiating the activity of pyrethroid insecticides. It is regulated as an insecticide active substance under EU Biocidal Products Regulation (BPR). While it may appear in insecticide products with potential incidental dermal exposure, PBO is not listed as an authorized cosmetic ingredient and has no recognized function in skincare or personal care cosmetic formulations.

Known concerns

  • No EU cosmetic ingredient authorization
  • Cytochrome P450 enzyme inhibition — drug interaction potential
  • Banned as intentional cosmetic ingredient — insecticide use only

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.