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Natural preservative

POLYEPSILON LYSINE HCL

CAS 73548-20-6
76

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

Polyepsilon-lysine HCl is a cationic biopolymer preservative with food-grade pedigree, used to protect formulations against microbial growth. It is generally gentle but cationic interactions limit use levels.

Skin benefits

  • Acts as a natural cationic antimicrobial preservative against bacteria and yeasts
  • Food-grade safety history supports its dermal use at typical levels
  • Helps reduce reliance on parabens and isothiazolinone preservatives
  • Biodegradable and water-soluble, easing rinse-off formulation

Known concerns

  • Cationic nature may interact with anionic surfactants and reduce performance
  • Limited European cosmetic precedent compared with established preservatives
  • Potential for mild irritation in leave-on formulations at higher levels

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.