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POLYEPSILON LYSINE HCL

CAS 73548-20-6
92

Safety score · 0–100

Excellent

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A naturally-derived antimicrobial polypeptide from Streptomyces albulus, used as a food-grade and cosmetic preservative with excellent safety profile.

Polyepsilon lysine (ε-Poly-L-lysine) is a naturally occurring homo-polyamino acid produced by bacterial fermentation. It is GRAS (Generally Recognised As Safe) approved in food by FDA and EFSA, and widely used as an antimicrobial preservative. The HCl salt improves water solubility. No restriction applies under EU Regulation 1223/2009; it is not listed in Annex II (banned) or III (restricted). The polymer is biodegradable.

Skin benefits

  • Natural antimicrobial preservation of cosmetic products
  • Broad-spectrum activity against Gram-positive bacteria and some fungi
  • Non-sensitising at use concentrations

Known concerns

  • Generally recognised as safe; minimal concerns
  • Possible mild irritation at very high concentrations

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.