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POLYGAMMA-GLUTAMATE GLUTAMINE

89

Safety score · 0–100

Good

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Polygamma-Glutamate Glutamine is a cosmetic ingredient used in product formulations. Its specific function may vary between products. Exercise caution due to limited available safety data.

Polygamma-glutamate (γ-PGA) is a naturally occurring polymer produced via fermentation by Bacillus species, structurally similar to the naturally present polyglutamic acid in human skin. It is biodegradable, non-toxic, and demonstrates excellent water-binding capacity. No EU Annex II or III restrictions apply, and its safety record in cosmetic and food applications is extensive, supporting a high safety score.

Skin benefits

  • Powerful natural humectant retaining up to 5000x its weight in water
  • Forms a hydrating film on the skin surface reducing transepidermal water loss
  • Supports skin elasticity and smoothness
  • Biodegradable and environmentally benign

Known concerns

  • Generally regarded as safe; no significant concerns identified

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.