Skip to content

Preservative

Polyhexamethylene biguanide hydrochloride

CAS 32289-58-0 [1]/ 27083-27-8 [2]/ 28757-47-3 [3]/ 133029-32-0 [4] Updated
30

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A polymeric biguanide preservative. Effective antimicrobial but classified as a suspected carcinogen by inhalation; EU caps it at 0.1% and bans use in sprays.

Skin benefits

  • Broad-spectrum biocide preservative
  • Effective at low concentration

Known concerns

  • CLP Carc. 2 (suspected human carcinogen by inhalation)
  • SCCS restricts max 0.1% in cosmetics, banned in spray products
  • Skin and respiratory sensitiser

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

Related preservatives

Check your shelf

Find Polyhexamethylene biguanide hydrochloride in your products.

Scan any cosmetic product with LuxSense to see if it contains Polyhexamethylene biguanide hydrochloride and get a full ingredient breakdown with safety scores.

This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.