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Pharmaceutical anesthetic

Pramocaine (INN)

CAS 140-65-8
35

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

Pramocaine is a topical local anesthetic regulated as a pharmaceutical, not a cosmetic. Its use in over-the-counter skin products is restricted, and it can cause sensitization or, rarely, methemoglobinemia.

Skin benefits

  • Topical local anesthetic effective for itching, minor burns and hemorrhoidal discomfort
  • Rapid onset and short duration on mucous membranes

Known concerns

  • Pharmaceutical active, not a cosmetic ingredient under EU definitions
  • Can cause contact dermatitis and sensitization
  • Risk of methemoglobinemia in infants and at high doses
  • Not authorized for general cosmetic use; regulated as a drug

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.