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Pramocaine (INN)

CAS 140-65-8
32

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Pramocaine (inn) is a cosmetic ingredient. Exercise caution due to limited available safety data.

Pramocaine (pramoxine) is a surface anaesthetic compound used for its numbing properties. Its inclusion in EU Annex III with restrictions at concentrations >=0.1% reflects the pharmacological nature of this ingredient. While not banned outright, the threshold reflects the desire to limit pharmacological effects in cosmetic products. It has been used in some personal care products for its sensory effects.

Skin benefits

  • Local anaesthetic effect in formulations
  • Temporary numbing sensation

Known concerns

  • EU Annex III restricted at >=0.1%
  • Local anaesthetic pharmacological activity
  • Potential for sensitisation

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.