Probenecid (INN)
Safety score · 0–100
Avoid
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
Probenecid (inn) is a cosmetic ingredient. Exercise caution due to limited available safety data.
Probenecid is a pharmaceutical agent belonging to the sulfonamide class used clinically as a uricosuric to treat gout and hyperuricemia. While not primarily a cosmetic ingredient, EU cosmetics regulation captures it under Annex III restrictions at ≥0.1% concentration. It shows moderate acute oral toxicity (H302) and its pharmacological activity (renal tubular transport inhibition) raises concerns about systemic effects if absorbed through skin. Restricted use in cosmetic products reflects the pharmaceutical origin and mechanism of action.
Known concerns
- Pharmacological activity concern
- Acute oral toxicity H302
- Restricted to ≤0.1% in EU cosmetics
- Systemic effects from skin absorption
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.