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Propiolactone

CAS 57-57-8
6

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Propiolactone is a cosmetic ingredient. Exercise caution due to limited available safety data.

beta-Propiolactone (CAS 57-57-8) is a reactive lactone that was previously used as a sterilizing agent and intermediate in cosmetic formulations. EU Regulation 1223/2009 Annex II prohibits its use in cosmetic products. The compound carries hazard statements including H227 (combustible liquid), H301 (toxic if swallowed), H315 (causes skin irritation), H317 (may cause allergic skin reaction), H319 (causes serious eye irritation), H330 (fatal if inhaled), H335 (may cause respiratory irritation), H340 (may cause genetic defects), H350 (may cause cancer), and H351 (suspected of causing cancer). The compound is classified as a Group 2A probable human carcinogen by IARC.

Known concerns

  • EU Annex II banned - probable human carcinogen
  • Confirmed mutagen (H340)
  • Suspected carcinogen (H350)
  • Acute toxicity by inhalation (H330)
  • Skin and respiratory sensitizer (H317/H335)
  • Extremely reactive lactone structure

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.