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Skin Conditioning

PYROGLUTAMYLAMIDOETHYL INDOLE

CAS -
70

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A synthetic indole-pyroglutamate derivative used for skin conditioning. Novel, with thin public safety data.

Pyroglutamylamidoethyl indole is a synthetic small molecule that pairs an indole ring (bioinspired by endogenous indoles and tryptophan) with an amide-linked pyroglutamic acid residue via an ethyl spacer. Pyroglutamate itself is a natural humectant in the skin, so the design intent is to deliver indole signalling with humectant balance. EU CosIng lists it for skin-conditioning function; no Annex II/III restriction. No CIR or SCCS review. Cosmetic-specific data is supplier-led, so scored conservatively.

Function

SKIN PROTECTING

Skin benefits

  • Synthetic indole conjugate for skin conditioning
  • Pyroglutamate moiety supports humectant behaviour
  • Low sensitization reported

Known concerns

  • Novel molecule with limited public safety data
  • No established CIR or SCCS review
  • Niche supplier ingredient

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.