QUATERNIUM-22
Other
Good
CAS Number: 51812-80-7 / 82970-95-4
About QUATERNIUM-22
A conditioning agent mainly for hair — tames static, adds softness, and improves manageability. CIR-reviewed and considered safe.
Detailed Analysis
Quaternium-22 (CAS 51812-80-7) is a quaternary ammonium compound functioning as an antistatic agent, film former, and hair fixative in cosmetic formulations, primarily used in rinse-off hair products at concentrations up to 2%. The CIR Expert Panel concluded it is safe in current practices of use. As a large, highly polar molecule, it is unlikely to be absorbed through the skin, minimizing systemic toxicity risk. It showed no skin irritation or sensitization in available studies. It is non-genotoxic in bacterial assays. Unreacted monomer content is low and not a toxicological concern.
Skin Benefits
- ✓ Effective antistatic agent for hair
- ✓ Film-forming properties
- ✓ Improves hair manageability and feel
- ✓ Non-irritating and non-sensitizing
Known Concerns
- ⚠ Limited mammalian genotoxicity and carcinogenicity data
- ⚠ Quaternary ammonium compounds may rarely cause irritation on damaged skin
Safety Score
Good
Based on EU regulatory data, published safety research, and ingredient function analysis.
References
EU CosIng Database
European Commission cosmetic ingredient registry
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