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Epoxide intermediate (banned, CMR)

R-1-Chloro-2,3-epoxypropane

CAS 51594-55-9
4

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

An industrial chemical (the chiral form of epichlorohydrin) banned from EU cosmetics as a probable human carcinogen and skin sensitiser. It has no skincare role and is a substance of very high concern.

Skin benefits

  • No cosmetic benefit; this is the (R)-enantiomer of epichlorohydrin, an industrial chemical intermediate
  • Named on cosmetic prohibition lists only to make the ban unambiguous

Known concerns

  • Listed in EU Cosmetics Regulation Annex II as a prohibited CMR substance
  • Epichlorohydrin is classified Carc. 1B and Muta. 2 under EU CLP
  • Strong skin sensitiser and corrosive irritant
  • IARC Group 2A (probably carcinogenic to humans)

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.