R-1-Chloro-2,3-epoxypropane

About R-1-Chloro-2,3-epoxypropane

R-1-Chloro-2,3-epoxypropane is a cosmetic ingredient used in product formulations. Its specific function may vary between products. Exercise caution due to limited available safety data.

Detailed Analysis

R-1-Chloro-2,3-epoxypropane (epichlorohydrin) carries the most severe harmonised classifications under EU CLP Regulation: H226 (flammable), H301+H311+H331 (acute toxicity categories 3), H314 (skin corrosion category 1B), H317 (skin sensitisation category 1), H318 (serious eye damage category 1), H330 (acute toxicity category 2), H334 (respiratory sensitisation category 1), H335 (STOT-SE category 3), H341 (germ cell mutagenicity category 2), H350 (carcinogenicity category 1B), H361 (reproductive toxicity category 2), H370 (STOT category 1), H371 (STOT category 2), H372 (STOT repeated exposure category 2). It is classified as a CMR (Carcinogen, Mutagen, Reproductive toxicant) substance. In cosmetics, epichlorohydrin may appear as an impurity in ethoxylated ingredients rather than as an intentional additive. Under Regulation (EC) No 1223/2009 Annex II, substances classified as CMR 1A/1B are prohibited in cosmetic products.

Known Concerns

• ⚠ CMR substance (Carcinogen 1B, Mutagen 2, Reproductive toxicant 2)
• ⚠ Skin corrosion (H314)
• ⚠ Respiratory sensitisation (H334)
• ⚠ Skin sensitisation (H317)
• ⚠ Acute toxicity (H301/H311/H331)
• ⚠ Eye damage (H318)
• ⚠ Prohibited in cosmetic products under EU Annex II

References