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Conditioning Agent

R-CLOSTRIDIUM HISTOLYTICUM COLLAGENASE H HEXAPEPTIDE-40

72

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A fusion of bacterial collagenase and a synthetic hexapeptide, designed to promote extracellular matrix remodelling in skin.

This recombinant fusion combines a Clostridium-derived collagenase domain with Hexapeptide-40, expressed in E. coli. Bacterial collagenases are enzymes capable of degrading collagen and are generally restricted in EU cosmetics to low concentrations to avoid tissue irritation. The peptide component is a short synthetic sequence with no known toxicity. Combined, the ingredient occupies a borderline safety profile — effective at low concentrations but requiring careful formulation controls due to enzymatic activity.

Function

SKIN CONDITIONING

Skin benefits

  • May assist skin remodelling by selectively degrading damaged collagen
  • Hexapeptide component may provide targeted peptide signalling

Known concerns

  • Enzymatic collagenase activity may cause irritation at higher concentrations
  • EU Annex III restricts enzyme-based cosmetic ingredients to prevent tissue damage
  • Risk of sensitisation from bacterial protein contaminants

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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Same plant / compound family

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R-CLOSTRIDIUM HISTOLYTICUM COLLAGENASE G HEXAPEPTIDE-40
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R-CLOSTRIDIUM HISTOLYTICUM COLLAGENASE H
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R-CLOSTRIDIUM HISTOLYTICUM COLLAGENASE H SH-OLIGOPEPTIDE-60
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.