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Skin Conditioning

RH-POLYPEPTIDE-5

CAS 76057-06-2
70

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A lab-made copy of human TGF-beta3 — a tissue-remodeling signal protein. Used at minute doses for skin conditioning, but its growth-factor activity earns it a cautious tier.

Function

SKIN CONDITIONING

Skin benefits

  • Recombinant TGF-beta3 analog modulates skin remodeling
  • Used at very low cosmetic doses
  • E. coli expression enables high purity

Known concerns

  • TGF-beta growth factor activity raises theoretical concerns
  • EU Annex II/416 references suggest restricted use
  • Long-term topical safety data limited

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.