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Botanical Extract

ROSA RUGOSA CALLUS EXTRACELLULAR VESICLES

72

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Rugosa-rose plant extracellular vesicles — a novel biotech active with antioxidant cargo. Promising but early-stage science.

Rosa Rugosa Callus Extracellular Vesicles are nano-sized lipid-bilayer vesicles isolated from bioreactor-grown rugosa rose callus cultures. Like mammalian exosomes, plant EVs carry polyphenols, lipids, proteins and small RNAs, and have attracted research interest for potential anti-inflammatory and regenerative effects. As a cosmetic ingredient they are positioned as a novel antioxidant delivery system. The scientific case is interesting but immature: most published data is in vitro or pre-clinical, plant-EV-to-human-skin translational evidence is thin, and several regulators (notably the US FDA regarding "exosome" claims) have warned about overstatement. Topical safety at cosmetic concentrations appears good, but there is no CIR/SCCS specific clearance, and particle standardization varies.

Skin benefits

  • Antioxidant polyphenol cargo
  • Sustainable biotech source
  • Novel vesicle-based delivery concept

Known concerns

  • Early-stage science on plant-EV human-skin effect
  • No CIR/SCCS evaluation
  • Regulatory scrutiny on 'exosome' marketing
  • Standardization varies by supplier

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.