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Skin Conditioning

SH-DS PHOSPHOROTHIOATE RNA-2 CHOLESTEROL

38

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A cholesterol-conjugated phosphorothioate siRNA — chemistry borrowed from therapeutic gene-silencing drugs, not a typical cosmetic ingredient. No SCCS opinion and class-level immune and off-target concerns warrant strong caution.

Skin benefits

  • Theoretical gene-silencing payload
  • Lipid-conjugated delivery

Known concerns

  • Phosphorothioate siRNAs have therapeutic-class hazards
  • Off-target binding and immune activation potential
  • No SCCS opinion for cosmetic use
  • Cholesterol conjugation enhances cellular uptake
  • Sparse topical safety data

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.