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biotech nucleic acid active

SH-DSRNA-2 HYDROXYPROPYL PEG-3 PROPYL CHOLESTERYLCARBAMATE

48

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A synthetic short double stranded RNA conjugated to a PEG cholesterol carbamate carrier. It is marketed for targeted skin signaling, but lacks public regulatory safety review, so its risk profile remains uncertain.

Skin benefits

  • Synthetic short double stranded RNA conjugate for targeted skin signaling
  • Cholesteryl carbamate anchor improves delivery into skin lipids
  • PEGylation can improve stability in formulations
  • Marketed as an advanced anti aging biotech active

Known concerns

  • No CIR or SCCS opinion on this novel RNA conjugate
  • Off target gene modulation and immune activation potential
  • PEG and cholesterol delivery vehicles can trigger sensitization
  • Very limited public peer reviewed safety data

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.