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SH-NONAPEPTIDE-18 SP TRIPEPTIDE-126 CHOLESTEROL

75

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A dual-peptide conjugated to cholesterol, designed to target multiple skin concerns including aging, pigmentation, and skin-barrier support.

sh-Nonapeptide-18 SP Tripeptide-126 Cholesterol is a synthetic peptide-cholesterol conjugate combining two peptide sequences (sh-Nonapeptide-18 SP and Tripeptide-126) with cholesterol. The cholesterol conjugation may support improved skin lipid barrier function. Not restricted under EU Cosmetics Regulation 1223/2009, though the complexity of the conjugate warrants attention to purity specifications.

Skin benefits

  • May support skin-barrier lipid function
  • Potential anti-aging, firming, and brightening benefits

Known concerns

  • Cholesterol may contribute to milia or comedones in acne-prone skin
  • Complex conjugate may present rare sensitization risk

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.