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Growth-factor-like biotech peptide

SH-OLIGOPEPTIDE-1 ALANYL SR-SPIDER OLIGOPEPTIDE-1

50

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

Conjugate of recombinant EGF-like SH-oligopeptide-1 with alanyl-linked spider oligopeptide-1. No dedicated review; growth-factor analogy and novel spider-derived sequence drive cautious orange rating.

Function

SKIN PROTECTING

Skin benefits

  • SH-oligopeptide-1 corresponds to recombinant EGF-like motif with documented in vitro activity
  • Alanyl linker to spider-derived oligopeptide may target structural protein pathways
  • Synthetic origin avoids harvesting from spiders

Known concerns

  • Spider-derived oligopeptide-1 motif lacks published cosmetic safety dossier
  • Growth-factor-like SH-oligopeptide-1 has been controversial in cosmetics due to theoretical proliferation concerns
  • No dedicated SCCS or CIR opinion for this conjugate
  • Novel chemistry raises sensitization uncertainty

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.