Conditioning Agent
SH-OLIGOPEPTIDE-16
Safety score · 0–100
Good
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A recombinant human chemokine analogue targeting skin inflammation and barrier dysfunction pathways.
This recombinant human peptide is synthesised to match the sequence of CX3CL1 (fractalkine), a chemokine involved in immune cell recruitment and skin homeostasis. Produced via E. coli fermentation with up to 397 amino acids, it is regulated under EU Annex II entry 416. The CosIng record notes a restriction for 'ban substances that deplete the ozone layer' — this appears to be a database classification error unrelated to the actual recombinant peptide, which contains no ozone-depleting compounds. The ingredient's chemokine-like activity may provide anti-inflammatory benefits at low cosmetic concentrations.
Function
Skin benefits
- May reduce skin inflammation through chemokine receptor modulation
- Potential for improving skin barrier function
Known concerns
- Chemokine activity — possible immune activation in reactive skin types
- Database restriction flag appears misapplied (likely a CosIng data error)
- Trace E. coli contaminants require monitoring
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related conditioning agents
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.