Humectant
SH-OLIGOPEPTIDE-9
Safety score · 0–100
Fine
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A recombinant human peptide produced in E. coli — designed to mimic enkephalin for skin hydration, conditioning, and protection. Biotech-derived with limited published safety data.
sh-Oligopeptide-9 is a single-chain recombinant human peptide (11 amino acids) produced by fermentation in E. coli, identical to the human gene coding for enkephalin. Contains up to 267 amino acids in the starting sequence, with the final product being 11 amino acids. Functions as a humectant, skin conditioner, and skin protector. As a biotech-derived ingredient identical to a human protein, it should have excellent biocompatibility. No GHS hazards listed.
Function
Skin benefits
- Humectant — attracts moisture
- Skin conditioning and protection
- Bioidentical to human enkephalin
Known concerns
- Recombinant E. coli-derived — potential for residual bacterial components
- Limited published independent safety data
- Novel biotech ingredient
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related humectants
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.