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Synthetic peptide salt

SH-PENTAPEPTIDE-6 TRIFLUOROACETATE

75

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A synthetic pentapeptide stabilized as a trifluoroacetate salt, used in anti-aging skincare. Tolerated well on skin, although the TFA counter-ion raises environmental persistence questions.

Function

SKIN CONDITIONING - MISCELLANEOUS

Skin benefits

  • Synthetic peptide marketed for skin renewal and firmness
  • Used at very low concentrations
  • Generally non-irritating in finished formulas

Known concerns

  • Trifluoroacetate counter-ion is environmentally persistent (PFAS-adjacent)
  • Limited published clinical evidence for skin claims
  • Cost may drive low actual concentrations in products

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.