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Conditioning Agent

SH-POLYPEPTIDE-103

82

Safety score · 0–100

Good

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A recombinant human heat shock protein — helps protect skin cells from stress and environmental damage.

sh-Polypeptide-103 is a recombinant human Heat Shock Protein beta-2 (HSPB2) produced in E. coli, containing up to 182 amino acids. Heat shock proteins are molecular chaperones that protect cells from thermal, oxidative, and UV stress. In cosmetics, it functions as a skin protectant. No GHS hazards, no EU restrictions. Used at trace concentrations for cellular stress defense.

Function

SKIN PROTECTING

Skin benefits

  • Cellular stress protection
  • Skin protecting
  • Anti-aging potential

Known concerns

  • Recombinant protein — limited topical efficacy data
  • Theoretical immunogenicity

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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Check your shelf

Find SH-POLYPEPTIDE-103 in your products.

Scan any cosmetic product with LuxSense to see if it contains SH-POLYPEPTIDE-103 and get a full ingredient breakdown with safety scores.

This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.