Conditioning Agent
SH-POLYPEPTIDE-120
Safety score · 0–100
Good
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A recombinant human E2F transcription factor 4 protein of 413 amino acids produced in E. coli for skin conditioning.
A single-chain recombinant human E2F Transcription Factor 4 protein synthesized from the human E2F4 gene, produced in E. coli. Contains up to 413 amino acids with possible disulfide bonds and/or glycosylation. E2F transcription factors are nuclear proteins regulating cell cycle; while the recombinant version is used topically, standard cosmetic safety monitoring applies under EU EC 1223/2009.
Function
Skin benefits
- Skin conditioning through transcription factor modulation
Known concerns
- Large protein size increases immunogenicity risk
- Limited long-term human safety data for topical cosmetic use
- Potential for sensitization with repeated exposure
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related conditioning agents
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.