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Skin Conditioning

SH-POLYPEPTIDE-138

Updated
75

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A lab-made peptide modeled on a portion of the human Sirtuin-6 protein, used for skin conditioning. Anti-aging claims rest on mechanism more than topical evidence; CIR/SCCS review is absent.

Function

SKIN CONDITIONING - MISCELLANEOUS

Skin benefits

  • Skin conditioning
  • Anti-aging mechanistic inspiration from SIRT6
  • Recombinant origin avoids animal-derived contaminants

Known concerns

  • No CIR or SCCS review
  • Topical bioavailability of sirtuin-related peptides is unproven
  • Limited published cosmetic safety data

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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ACTINIDIA POLYGAMA FRUIT EXTRACT
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.