Skip to content

Conditioning Agent

SH-POLYPEPTIDE-17

82

Safety score · 0–100

Good

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A recombinant human interleukin-1 alpha analogue produced in E. coli, used in skin conditioning formulations.

This recombinant human peptide mirrors interleukin-1 alpha, a pro-inflammatory cytokine involved in wound healing and skin homeostasis. Produced by E. coli fermentation with a maximum of 272 amino acids, it contains only standard amino acids. The EU classifies recombinant cytokines and analogues under Annex II entry 416. While IL-1α has potent biological activity, topical cosmetic use at low concentrations is generally considered safe; however, the cytokine-like nature of this ingredient requires careful formulation to avoid inflammatory responses.

Function

SKIN CONDITIONING

Skin benefits

  • May stimulate wound healing and skin repair cascades
  • Potential for supporting skin barrier homeostasis

Known concerns

  • Cytokine-like activity — potential for pro-inflammatory responses in sensitive skin
  • Trace endotoxin risk from E. coli production system
  • Not recommended for use on compromised or inflamed skin

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

Related conditioning agents

82
ACETYL HEXAPEPTIDE-68 AMIDE ACETATE
Conditioning Agent
 82
ACETYL SH-OLIGOPEPTIDE-30 SP
Conditioning Agent
 82
ACTINIDIA POLYGAMA LEAF/STEM EXTRACT
Conditioning Agent
 82
ANTENNARIA DIOICA CALLUS EXTRACT
Conditioning Agent
 82
BACILLUS FERMENT FILTRATE EXTRACT
Conditioning Agent
 82
BACILLUS/SEA SALT FERMENT FILTRATE
Conditioning Agent
 82
BUTYL HYDROXYCYCLOHEXANE CARBOXYLATE
Conditioning Agent
 82
BUTYROYL SH-PENTAPEPTIDE-12 SP
Conditioning Agent

Check your shelf

Find SH-POLYPEPTIDE-17 in your products.

Scan any cosmetic product with LuxSense to see if it contains SH-POLYPEPTIDE-17 and get a full ingredient breakdown with safety scores.

This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.