Emollient
SH-POLYPEPTIDE-58
Safety score · 0–100
Good
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
A recombinant human TIMP-1 metalloproteinase inhibitor protein produced in E. coli for emollient and skin protection.
A single-chain synthetic human peptide corresponding to Tissue Inhibitor of Metalloproteinases 1, produced via E. coli fermentation. Contains up to 207 amino acids with possible disulfide bonds and/or glycosylation. TIMP-1 is a endogenous protein that regulates matrix metalloproteinases; topical cosmetic use is generally well-tolerated under EU regulation EC 1223/2009.
Function
Skin benefits
- Skin conditioning emollient effect
- Skin conditioning and protection via MMP inhibition
Known concerns
- Limited long-term human safety data for topical cosmetic use
- Potential for sensitization with repeated exposure
References
EU CosIng database
European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.
Related emollients
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.