Conditioning Agent
SH-POLYPEPTIDE-86
Safety score · 0–100
Good
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
Synthetic human follistatin protein — a bioactive peptide that may support skin renewal by modulating growth factor activity.
sh-Polypeptide-86 is a synthetic human-identical follistatin produced by E. coli fermentation. Contains up to 344 amino acids with potential disulfide bonds and glycosylation. CosIng-listed for skin conditioning. Follistatin is a natural activin-binding protein that modulates TGF-β superfamily signaling, potentially influencing skin cell proliferation and differentiation. No GHS codes or restrictions. Large protein — primarily surface-active in cosmetic use.
Function
Skin benefits
- Skin conditioning
- Growth factor modulation (follistatin mechanism)
- Potential skin renewal support
Known concerns
- Large protein — very limited skin penetration
- Growth factor modulator — theoretical concerns about cell proliferation
- Recombinant E. coli-produced — requires thorough purification
References
EU CosIng database
European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.
Related conditioning agents
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.