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Skin Conditioning

SINOPODOPHYLLUM HEXANDRUM CALLUS EXTRACT

Updated
45

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A callus extract from Himalayan mayapple (Sinopodophyllum hexandrum), a plant whose roots produce the cytotoxic compound podophyllotoxin. Limited public safety data on the cosmetic callus form — used with caution.

Function

SKIN CONDITIONING - HUMECTANT

Skin benefits

  • Phenolic antioxidants from cell culture
  • Marketed for skin conditioning
  • Sustainable lab-cultured sourcing

Known concerns

  • Parent plant produces podophyllotoxin — a cytotoxic, antimitotic alkaloid
  • Callus tissue can also synthesize lignan toxins under some culture conditions
  • No formal CIR/SCCS review of this specific extract
  • Default-down placement until purity profile is publicly reviewed

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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ASIVATREP
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.