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Skin Conditioning

STEPHANIA TETRANDRA ROOT EXTRACT

CAS 223748-82-1 Updated
50

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Stephania tetrandra root extract used in TCM-style skincare. Concern: historic adulteration in this genus with nephrotoxic Aristolochia means sourcing and species verification are critical.

Function

SKIN CONDITIONING

Skin benefits

  • Tetrandrine alkaloid with anti-inflammatory studies
  • Antioxidant content
  • Traditional TCM use

Known concerns

  • Genus Stephania has historic adulteration with nephrotoxic Aristolochia (aristolochic acid is IARC Group 1)
  • Bisbenzylisoquinoline alkaloids carry pharmacological activity
  • Limited cosmetic-specific safety review
  • Sourcing/identification critical

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.