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Strophantines, their aglucones and their respective derivatives

CAS 11005-63-3
5

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A cosmetic ingredient. Raw material has significant toxicity. Exercise caution due to limited available safety data.

Strophanthins (including ouabain, k-strophanthin) are cardiotonic glycosides from Strophanthus species. They inhibit Na+/K+-ATPase with potency similar to digitalis glycosides. EU CLP classification includes H301/H331 (toxic if swallowed/inhaled) and H373 (organ toxicity). The EU Cosmetics Regulation Annex II prohibits these compounds due to their extreme cardiac toxicity and narrow safety margin. Even trace dermal absorption could produce life-threatening cardiac arrhythmias.

Known concerns

  • Cardiac glycoside toxicity
  • Na+/K+-ATPase inhibitor
  • Narrow therapeutic index
  • Acute toxicity H301/H331
  • Risk of fatal cardiac arrhythmias
  • Banned in EU cosmetics (Annex II)

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.