Skin Conditioning
SYNEPHRINE HCL
Safety score · 0–100
Moderate
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A sympathomimetic alkaloid (HCl salt) from bitter orange. Has measurable vasoactive effects and is controversial as a supplement; cosmetic use should be at very low levels with awareness of systemic risk.
Skin benefits
- Used as a skin-conditioning alkaloid in some Asian formulas
- Reported vasoconstrictor effects in topical research
Known concerns
- Sympathomimetic activity — cardiovascular concerns if absorbed
- Pregnancy and cardiovascular contraindications when oral
- Limited cosmetic safety review
- Better known as a controversial supplement
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related skin conditionings
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.