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Tetrabenazine (INN) and its salts

CAS 58-46-8
15

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Tetrabenazine (inn) And Its Salts is a cosmetic ingredient. Exercise caution due to limited available safety data.

Tetrabenazine is a VMAT2 inhibitor pharmaceutical used clinically for chorea associated with Huntington's disease and hyperkinetic movement disorders. Its mechanism of action involves depletion of dopamine, norepinephrine, and serotonin from nerve terminals. The EU Cosmetics Regulation Annex III restricts tetrabenazine and its salts at ≥0.1% in cosmetic products. Acute oral toxicity is noted (H302), and its CNS pharmacological activity makes topical cosmetic use inappropriate.

Known concerns

  • CNS pharmacological activity
  • Monoamine depletion mechanism
  • Acute oral toxicity H302
  • Restricted to ≤0.1% in EU cosmetics

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.