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Skin Conditioning

TETRAHYDROPALMATINE HCL

CAS 6024-85-7 Updated
45

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A bioactive isoquinoline alkaloid (HCl salt) used historically as a sedative and analgesic. Pharmacologically active and not really suited to cosmetic use — best handled as a botanical drug.

Skin benefits

  • Studied as a CNS-active alkaloid
  • Reported antinociceptive and anxiolytic effects in animal models

Known concerns

  • Pharmacologically active alkaloid — sedative and dopaminergic effects
  • Hepatotoxicity reports in supplement context
  • Not appropriate for routine cosmetic exposure
  • Limited topical safety review

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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ASIVATREP
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.