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TETRAHYDROPALMATINE

CAS 483-14-7
38

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Tetrahydropalmatine is a cosmetic ingredient. Raw material has significant toxicity. Exercise caution due to limited available safety data.

Tetrahydropalmatine is an isoquinoline alkaloid found in various Corydalis and Stephabrotia species, used in traditional medicine. It carries H300 (fatal if swallowed) and H302 (harmful if swallowed) classifications. While explored therapeutically for pain management, its narrow therapeutic index and lack of comprehensive cosmetic safety data limit its suitability for skincare formulations.

Skin benefits

  • Analgesic properties (traditional use)

Known concerns

  • Acute oral toxicity (H300/H302)
  • Narrow therapeutic index
  • Limited cosmetic safety data

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.