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Synthetic alkaloid derivative

TETRAHYDROPIPERINE

CAS 23434-88-0
60

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

Tetrahydropiperine is a hydrogenated derivative of black pepper piperine used as a penetration enhancer and tanning booster. It is effective at low doses but enhances absorption of other ingredients.

Skin benefits

  • Marketed as bioavailability enhancer and self-tanning booster
  • Lipid-soluble, integrates into oil-phase formulations
  • Used at very low percentages typically below 0.5%

Known concerns

  • Piperine analogues can act as penetration enhancers, raising absorption of other actives
  • Limited long-term human skin safety data
  • Potential sensitisation on compromised skin barriers

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.