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Skin Conditioning

TETRAPEPTIDE-44 NICOTINATE

65

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A four-amino-acid synthetic peptide esterified with niacin — for skin conditioning. Generally well tolerated; mild flushing possible in sensitive users.

Tetrapeptide-44 Nicotinate is a synthetic tetrapeptide chemically conjugated to nicotinic acid (niacin). The combination is intended to leverage peptide carrier behavior together with the vasoactive/skin-conditioning effects of niacin esters. Niacin esters are well known in topical cosmetics; they can cause transient warmth or flushing in sensitive users at higher percentages but are well tolerated at typical levels. No CIR or SCCS opinion exists. Independent peer-reviewed efficacy data is essentially absent; claims rely on supplier in vitro work.

Function

SKIN CONDITIONING

Skin benefits

  • Skin conditioning
  • Niacin-mediated microcirculation effects
  • Low irritation at typical levels

Known concerns

  • Possible transient flushing in sensitive users
  • Limited independent data
  • No regulatory dossier

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.