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Skin Conditioning

TETRAPEPTIDE-45

CAS 775345-53-4
86

Safety score · 0–100

Good

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A synthetic four-amino-acid peptide built from arginine, glutamic acid, serine, and threonine. Marketed for hydration and reducing the look of aging; safe at ppm cosmetic doses.

Function

SKIN CONDITIONING

Skin benefits

  • Skin conditioning peptide
  • Marketed for hydration support and wrinkle reduction
  • Used at very low ppm — minimal irritation potential
  • Well-defined synthetic sequence

Known concerns

  • Efficacy claims largely supplier-driven
  • Theoretical sensitization (rare for peptides)

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.