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Skin Conditioning

TETRAPEPTIDE-81

70

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A four-amino-acid synthetic peptide used at trace levels for skin-signaling claims. Safety profile is good; efficacy data are mostly proprietary.

Tetrapeptide-81 is a short synthetic peptide of four amino acids sold by ingredient suppliers as an active for anti-aging or skin-conditioning formulations. Use levels are typically very low (parts per million), and the peptide itself does not raise toxicological concerns at cosmetic concentrations. There is no formal CIR or SCCS review for this specific peptide; safety judgment derives from the broader tetrapeptide class, which has a clean tolerance and irritation record. Public efficacy evidence is usually limited to supplier brochures and small in-vitro studies.

Function

SKIN CONDITIONING - EMOLLIENT

Skin benefits

  • Marketed for cell-signaling support
  • Trace-level active
  • Smooth skin feel

Known concerns

  • Limited public efficacy data
  • Proprietary characterization
  • Stability challenges in formulation

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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Check your shelf

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.