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Hair Conditioning

THIODIGLYCOL

CAS 111-48-8
65

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

Thiodiglycol — a useful reducing agent in hair dyes, but also an OPCW Schedule 2 chemical, which imposes trade restrictions.

Thiodiglycol (CAS 111-48-8) is a thioether diol used in cosmetics primarily as a reducing and conditioning agent in oxidative hair colour systems and some skin conditioning formulations. Its classic regulatory flag is that it is listed on Schedule 2 of the OPCW Chemical Weapons Convention as a precursor to sulfur mustard, which imposes trade and reporting obligations on manufacturers and some jurisdictional limits on use. In cosmetic formulations at typical sub-percentage levels, acute toxicity is low and sensitisation is uncommon. Prior database score of 85 was too high given the regulatory classification; corrected to mid-yellow.

Function

ANTIOXIDANT

Skin benefits

  • Hair dye adjunct
  • Reducing agent
  • Mild conditioning

Known concerns

  • OPCW Schedule 2 classification
  • Trade restrictions in some markets
  • Mild irritation
  • Not for leave-on at high %

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.