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TRI (GAMMA-GLUTAMYL CYSTEINYL) GLYCINE

87

Safety score · 0–100

Good

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A glutathione-like tripeptide that supports skin's antioxidant defense and detoxification pathways, generally regarded as safe with no EU restrictions.

Tri(gamma-glutamyl cysteinyl) glycine, essentially a glutathione tripeptide analog, is a synthetic peptide supporting skin's endogenous antioxidant defense system. Glutathione is a naturally occurring skin antioxidant that declines with age and UV exposure. Not restricted in EU Annexes. Peptide-based ingredients of this type are generally well-tolerated with low irritation and sensitization potential, though stability in formulation (oxidation) can be a challenge.

Skin benefits

  • Supports skin's natural antioxidant defense
  • Detoxification pathway support (phase II conjugation)
  • Skin brightening via tyrosinase inhibition
  • Anti-aging and pollution defense benefits

Known concerns

  • Formulation stability (oxidation sensitivity)
  • Limited penetration if not properly formulated

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.