TRIHYDROXYCHALCONE
Safety score · 0–100
Good
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
TRIHYDROXYCHALCONE is a cosmetic ingredient used in product formulation. Exercise caution due to limited available safety data.
Trihydroxychalcone (specifically isoliquiritigenin and related structures) is a flavonoid-class polyphenol found in licorice (Glycyrrhiza) species, functioning as an antioxidant and skin-brightening agent in cosmetic formulations. It is not restricted under EU Regulation 1223/2009 and has demonstrated good tolerability in skin sensitisation testing. Its ability to inhibit tyrosinase makes it a popular natural alternative to hydroquinone in brightening products.
Skin benefits
- Potent antioxidant protecting skin from free radical damage
- Skin-brightening through tyrosinase inhibition
- Anti-inflammatory properties beneficial for sensitive skin
Known concerns
- Generally well-tolerated with low concern
- Natural source variability may affect composition
References
EU CosIng database
European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.