TRIMETHYL-3-CYCLOHEXENE-1-METHANETHIOL
Safety score · 0–100
Fine
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A cyclic thiol (mercaptan) with a trimethylcyclohexene ring, used as a fragrance ingredient contributing sulfurous, citrus, and grapefruit notes. Thiols are potent odorants even at very low concentrations.
Trimethyl-3-Cyclohexene-1-Methanethiol is a cyclic mercaptan (thiol) with a trimethyl-substituted cyclohexene ring. Thiols are among the most potent fragrance materials, detectable at parts per billion levels, and this compound contributes citrus, grapefruit, and sulfurous notes. The thiol functional group (-SH) is reactive and can form disulfides or bind to skin proteins, potentially contributing to sensitization. It is not listed in EU Annex II (banned substances) or Annex III (restricted substances) of the Cosmetics Regulation.
Skin benefits
- Provides potent citrus, grapefruit fragrance at low concentrations
- Contributes to tropical and fresh fragrance compositions
Known concerns
- Thiol reactivity may contribute to skin sensitization
- Strong odor may cause respiratory irritation in sensitive individuals
- Can form oxidation products (disulfides) during storage
- Limited comprehensive toxicological data
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.